A catalogue of biochemically diverse CRISPR-Cas9 orthologs

Bacterial Cas9 nucleases from type II CRISPR-Cas antiviral defence systems have been repurposed as genome editing tools. Although these proteins are found in many microbes, only a handful of variants are used for these applications. Here, we use bioinformatic and biochemical analyses to explore this...

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Publicado no:Nat Commun
Main Authors: Gasiunas, Giedrius, Young, Joshua K., Karvelis, Tautvydas, Kazlauskas, Darius, Urbaitis, Tomas, Jasnauskaite, Monika, Grusyte, Mantvyda M., Paulraj, Sushmitha, Wang, Po-Hao, Hou, Zhenglin, Dooley, Shane K., Cigan, Mark, Alarcon, Clara, Chilcoat, N. Doane, Bigelyte, Greta, Curcuru, Jennifer L., Mabuchi, Megumu, Sun, Zhiyi, Fuchs, Ryan T., Schildkraut, Ezra, Weigele, Peter R., Jack, William E., Robb, G. Brett, Venclovas, Česlovas, Siksnys, Virginijus
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7606464/
https://ncbi.nlm.nih.gov/pubmed/33139742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19344-1
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