A catalogue of biochemically diverse CRISPR-Cas9 orthologs

Bacterial Cas9 nucleases from type II CRISPR-Cas antiviral defence systems have been repurposed as genome editing tools. Although these proteins are found in many microbes, only a handful of variants are used for these applications. Here, we use bioinformatic and biochemical analyses to explore this...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Gasiunas, Giedrius, Young, Joshua K., Karvelis, Tautvydas, Kazlauskas, Darius, Urbaitis, Tomas, Jasnauskaite, Monika, Grusyte, Mantvyda M., Paulraj, Sushmitha, Wang, Po-Hao, Hou, Zhenglin, Dooley, Shane K., Cigan, Mark, Alarcon, Clara, Chilcoat, N. Doane, Bigelyte, Greta, Curcuru, Jennifer L., Mabuchi, Megumu, Sun, Zhiyi, Fuchs, Ryan T., Schildkraut, Ezra, Weigele, Peter R., Jack, William E., Robb, G. Brett, Venclovas, Česlovas, Siksnys, Virginijus
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7606464/
https://ncbi.nlm.nih.gov/pubmed/33139742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19344-1
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