Suppression of HBV replication by the expression of nickase- and nuclease dead-Cas9

Complete removal of hepatitis B virus (HBV) DNA from nuclei is difficult by the current therapies. Recent reports have shown that a novel genome-editing tool using Cas9 with a single-guide RNA (sgRNA) system can cleave the HBV genome in vitro and in vivo. However, induction of a double-strand break...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Kurihara, Takeshi, Fukuhara, Takasuke, Ono, Chikako, Yamamoto, Satomi, Uemura, Kentaro, Okamoto, Toru, Sugiyama, Masaya, Motooka, Daisuke, Nakamura, Shota, Ikawa, Masato, Mizokami, Masashi, Maehara, Yoshihiko, Matsuura, Yoshiharu
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5522428/
https://ncbi.nlm.nih.gov/pubmed/28733609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-05905-w
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