Phylogeny of Cas9 determines functional exchangeability of dual-RNA and Cas9 among orthologous type II CRISPR-Cas systems

The CRISPR-Cas-derived RNA-guided Cas9 endonuclease is the key element of an emerging promising technology for genome engineering in a broad range of cells and organisms. The DNA-targeting mechanism of the type II CRISPR-Cas system involves maturation of tracrRNA:crRNA duplex (dual-RNA), which direc...

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Bibliografske podrobnosti
Main Authors: Fonfara, Ines, Le Rhun, Anaïs, Chylinski, Krzysztof, Makarova, Kira S., Lécrivain, Anne-Laure, Bzdrenga, Janek, Koonin, Eugene V., Charpentier, Emmanuelle
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2014
Teme:
Nucleic Acid Enzymes
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3936727/
https://ncbi.nlm.nih.gov/pubmed/24270795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1074
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