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Origins and evolution of CRISPR-Cas systems

CRISPR-Cas, the bacterial and archaeal adaptive immunity systems, encompass a complex machinery that integrates fragments of foreign nucleic acids, mostly from mobile genetic elements (MGE), into CRISPR arrays embedded in microbial genomes. Transcripts of the inserted segments (spacers) are employed...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Philos Trans R Soc Lond B Biol Sci
Main Authors: Koonin, Eugene V., Makarova, Kira S.
Format: Artigo
Jezik:Inglês
Izdano: The Royal Society 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6452270/
https://ncbi.nlm.nih.gov/pubmed/30905284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2018.0087
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