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RNA-Independent DNA Cleavage Activities of Cas9 and Cas12a
CRISPR-Cas systems provide bacteria and archaea with sequence-specific protection against invading mobile genetic elements. In the presence of divalent metal ions, Cas9 and Cas12a (formerly Cpf1) proteins target and cleave DNA that is complementary to a cognate guide RNA. The recognition of a protos...
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| Gepubliceerd in: | Cell Rep |
|---|---|
| Hoofdauteurs: | , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2017
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5760271/ https://ncbi.nlm.nih.gov/pubmed/29281823 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.11.100 |
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