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The bridge helix of Cas12a imparts selectivity in cis-DNA cleavage and regulates trans-DNA cleavage
Cas12a is an RNA-guided DNA endonuclease of the type V-A CRISPR-Cas system that has evolved convergently with the type II Cas9 protein. We previously showed that proline substitutions in the bridge helix (BH) impart target DNA cleavage selectivity in Streptococcus pyogenes (Spy) Cas9. Here, we exami...
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| 出版年: | FEBS Lett |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2021
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8044059/ https://ncbi.nlm.nih.gov/pubmed/33523494 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1873-3468.14051 |
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