Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc

Proper control of B cell growth and metabolism is crucial for B-cell-mediated immunity, but the underlying molecular mechanisms remain incompletely understood. In this study, Sin1, a key component of mTOR complex 2 (mTORC2), specifically regulates B cell growth and metabolism. Genetic ablation of Si...

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Detaylı Bibliyografya
Yayımlandı:Cell Mol Immunol
Asıl Yazarlar: Li, Man, Lazorchak, Adam S., Ouyang, Xinxing, Zhang, Huihui, Liu, Hongzhi, Arojo, Omotooke A., Yan, Lichong, Jin, Jingsi, Han, Yuheng, Qu, Guojun, Fu, Yuhong, Xu, Xiaocao, Liu, Xiaobo, Zhang, Wenqian, Yang, Zhengfeng, Ruan, Chuan, Wang, Qijun, Liu, Dou, Huang, Chuanxin, Lu, Lu, Jiang, Shibo, Li, Fubin, Su, Bing
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6804816/
https://ncbi.nlm.nih.gov/pubmed/30705387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41423-018-0185-x
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