Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc

Proper control of B cell growth and metabolism is crucial for B-cell-mediated immunity, but the underlying molecular mechanisms remain incompletely understood. In this study, Sin1, a key component of mTOR complex 2 (mTORC2), specifically regulates B cell growth and metabolism. Genetic ablation of Si...

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Publicado en:Cell Mol Immunol
Main Authors: Li, Man, Lazorchak, Adam S., Ouyang, Xinxing, Zhang, Huihui, Liu, Hongzhi, Arojo, Omotooke A., Yan, Lichong, Jin, Jingsi, Han, Yuheng, Qu, Guojun, Fu, Yuhong, Xu, Xiaocao, Liu, Xiaobo, Zhang, Wenqian, Yang, Zhengfeng, Ruan, Chuan, Wang, Qijun, Liu, Dou, Huang, Chuanxin, Lu, Lu, Jiang, Shibo, Li, Fubin, Su, Bing
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6804816/
https://ncbi.nlm.nih.gov/pubmed/30705387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41423-018-0185-x
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