Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc

Proper control of B cell growth and metabolism is crucial for B-cell-mediated immunity, but the underlying molecular mechanisms remain incompletely understood. In this study, Sin1, a key component of mTOR complex 2 (mTORC2), specifically regulates B cell growth and metabolism. Genetic ablation of Si...

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Publicat a:Cell Mol Immunol
Autors principals: Li, Man, Lazorchak, Adam S., Ouyang, Xinxing, Zhang, Huihui, Liu, Hongzhi, Arojo, Omotooke A., Yan, Lichong, Jin, Jingsi, Han, Yuheng, Qu, Guojun, Fu, Yuhong, Xu, Xiaocao, Liu, Xiaobo, Zhang, Wenqian, Yang, Zhengfeng, Ruan, Chuan, Wang, Qijun, Liu, Dou, Huang, Chuanxin, Lu, Lu, Jiang, Shibo, Li, Fubin, Su, Bing
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6804816/
https://ncbi.nlm.nih.gov/pubmed/30705387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41423-018-0185-x
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