Enhanced Mitochondrial Inhibition by 3,4-Dihydroxyphenyl-Acetaldehyde (DOPAL)-Oligomerized α-Synuclein

Oligomeric forms of α-synuclein are believed to cause mitochondrial injury, which may contribute to neurotoxicity in Parkinson’s disease (PD). Here oligomers of α-synuclein were prepared using the dopamine metabolite, DOPAL (3,4-dihydroxyphenyl-acetaldehyde), in the presence of guanidinium hydrochlo...

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Detalhes bibliográficos
Publicado no:J Neurosci Res
Main Authors: Sarafian, Theodore A., Yacoub, Amneh, Kunz, Anastasia, Aranki, Burkan, Serobyan, Grigor, Cohn, Whitaker, Whitelegge, Julian P, Watson, Joseph B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6801072/
https://ncbi.nlm.nih.gov/pubmed/31420910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jnr.24513
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