Exploring the Role of Methionine Residues on the Oligomerization and Neurotoxic Properties of DOPAL-Modified -Synuclein

The dopamine metabolite 3,4-dihydroxyphenylacetaldehyde (DOPAL) is believed to play a central role in Parkinson’s disease neurodegeneration by stabilizing potentially toxic oligomers of the presynaptic protein α-Synuclein (aSyn). Besides the formation of covalent DOPAL-Lys adducts, DOPAL treatment p...

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Publicat a:Biochem Biophys Res Commun
Autors principals: Gonçalves, Phelippe Carmo, do Nascimento, Lucas Alex, Cortines, Juliana R., Eliezer, David, Romão, Luciana, Follmer, Cristian
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6293985/
https://ncbi.nlm.nih.gov/pubmed/30249394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2018.09.111
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