Oligomerization and Membrane-binding Properties of Covalent Adducts Formed by the Interaction of α-Synuclein with the Toxic Dopamine Metabolite 3,4-Dihydroxyphenylacetaldehyde (DOPAL)

Oxidative deamination of dopamine produces the highly toxic aldehyde 3,4-dihydroxyphenylacetaldehyde (DOPAL), enhanced production of which is found in post-mortem brains of Parkinson disease patients. When injected into the substantia nigra of rat brains, DOPAL causes the loss of dopaminergic neuron...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Follmer, Cristian, Coelho-Cerqueira, Eduardo, Yatabe-Franco, Danilo Y., Araujo, Gabriel D. T., Pinheiro, Anderson S., Domont, Gilberto B., Eliezer, David
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2015
Schlagworte:
Protein Structure and Folding
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646016/
https://ncbi.nlm.nih.gov/pubmed/26381411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.686584
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