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Role of Parkinson’s Disease-linked Mutations and N-Terminal Acetylation on the Oligomerization of α-Synuclein Induced by DOPAL
Identifying the mechanisms by which the presynaptic protein α-synuclein (aSyn) is associated to neurodegeneration of dopamine neurons is a major priority in the Parkinson’s disease (PD) field. Studies indicate that DOPAL (3,4-dihydroxyphenylacetaldehyde), an aldehyde generated from the enzymatic oxi...
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| Опубликовано в: : | ACS Chem Neurosci |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6467814/ https://ncbi.nlm.nih.gov/pubmed/30352158 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.8b00498 |
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