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Exploring the Role of Methionine Residues on the Oligomerization and Neurotoxic Properties of DOPAL-Modified -Synuclein
The dopamine metabolite 3,4-dihydroxyphenylacetaldehyde (DOPAL) is believed to play a central role in Parkinson’s disease neurodegeneration by stabilizing potentially toxic oligomers of the presynaptic protein α-Synuclein (aSyn). Besides the formation of covalent DOPAL-Lys adducts, DOPAL treatment p...
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| Publicado no: | Biochem Biophys Res Commun |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6293985/ https://ncbi.nlm.nih.gov/pubmed/30249394 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2018.09.111 |
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