Distinct Functions for Anterograde and Retrograde Sorting of SORLA in Amyloidogenic Processes in the Brain

SORLA is a neuronal sorting receptor implicated both in sporadic and familial forms of AD. SORLA reduces the amyloidogenic burden by two mechanisms, either by rerouting internalized APP molecules from endosomes to the trans-Golgi network (TGN) to prevent proteolytic processing or by directing newly...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Dumanis, Sonya B., Burgert, Tilman, Caglayan, Safak, Füchtbauer, Annette, Füchtbauer, Ernst-Martin, Schmidt, Vanessa, Willnow, Thomas E.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6795211/
https://ncbi.nlm.nih.gov/pubmed/26377460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0427-15.2015
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