Multi-compartmental modeling of SORLA’s influence on amyloidogenic processing in Alzheimer’s disease

BACKGROUND: Proteolytic breakdown of the amyloid precursor protein (APP) by secretases is a complex cellular process that results in formation of neurotoxic Aβ peptides, causative of neurodegeneration in Alzheimer’s disease (AD). Processing involves monomeric and dimeric forms of APP that traffic th...

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Bibliografiska uppgifter
Huvudupphovsmän: Lao, Angelyn, Schmidt, Vanessa, Schmitz, Yvonne, Willnow, Thomas E, Wolkenhauer, Olaf
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2012
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3483162/
https://ncbi.nlm.nih.gov/pubmed/22727043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-6-74
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