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Multi-compartmental modeling of SORLA’s influence on amyloidogenic processing in Alzheimer’s disease
BACKGROUND: Proteolytic breakdown of the amyloid precursor protein (APP) by secretases is a complex cellular process that results in formation of neurotoxic Aβ peptides, causative of neurodegeneration in Alzheimer’s disease (AD). Processing involves monomeric and dimeric forms of APP that traffic th...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BioMed Central
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3483162/ https://ncbi.nlm.nih.gov/pubmed/22727043 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-6-74 |
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