Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease

The extent of proteolytic processing of the amyloid precursor protein (APP) into neurotoxic amyloid-β (Aβ) peptides is central to the pathology of Alzheimer's disease (AD). Accordingly, modifiers that increase Aβ production rates are risk factors in the sporadic form of AD. In a novel systems b...

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Detalhes bibliográficos
Main Authors: Schmidt, Vanessa, Baum, Katharina, Lao, Angelyn, Rateitschak, Katja, Schmitz, Yvonne, Teichmann, Anke, Wiesner, Burkhard, Petersen, Claus Munck, Nykjaer, Anders, Wolf, Jana, Wolkenhauer, Olaf, Willnow, Thomas E
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3252570/
https://ncbi.nlm.nih.gov/pubmed/21989385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.352
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