Dose‐linearity of the pharmacokinetics of an intravenous [(14)C]midazolam microdose in children

AIMS: Drug disposition in children may vary from adults due to age‐related variation in drug metabolism. Microdose studies present an innovation to study pharmacokinetics (PK) in paediatrics; however, they should be used only when the PK is dose linear. We aimed to assess dose linearity of a [(14)C]...

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Publicado no:Br J Clin Pharmacol
Main Authors: van Groen, Bianca D., Vaes, Wouter H., Park, B. Kevin, Krekels, Elke H.J., van Duijn, Esther, Kõrgvee, Lenne‐Triin, Maruszak, Wioleta, Grynkiewicz, Grzegorz, Garner, R. Colin, Knibbe, Catherijne A.J., Tibboel, Dick, de Wildt, Saskia N., Turner, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6783587/
https://ncbi.nlm.nih.gov/pubmed/31269280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.14047
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