Dose‐linearity of the pharmacokinetics of an intravenous [(14)C]midazolam microdose in children

AIMS: Drug disposition in children may vary from adults due to age‐related variation in drug metabolism. Microdose studies present an innovation to study pharmacokinetics (PK) in paediatrics; however, they should be used only when the PK is dose linear. We aimed to assess dose linearity of a [(14)C]...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Br J Clin Pharmacol
Main Authors: van Groen, Bianca D., Vaes, Wouter H., Park, B. Kevin, Krekels, Elke H.J., van Duijn, Esther, Kõrgvee, Lenne‐Triin, Maruszak, Wioleta, Grynkiewicz, Grzegorz, Garner, R. Colin, Knibbe, Catherijne A.J., Tibboel, Dick, de Wildt, Saskia N., Turner, Mark A.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2019
Teme:
Original Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6783587/
https://ncbi.nlm.nih.gov/pubmed/31269280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.14047
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki