Dose‐linearity of the pharmacokinetics of an intravenous [(14)C]midazolam microdose in children

AIMS: Drug disposition in children may vary from adults due to age‐related variation in drug metabolism. Microdose studies present an innovation to study pharmacokinetics (PK) in paediatrics; however, they should be used only when the PK is dose linear. We aimed to assess dose linearity of a [(14)C]...

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Publicado en:Br J Clin Pharmacol
Autores principales: van Groen, Bianca D., Vaes, Wouter H., Park, B. Kevin, Krekels, Elke H.J., van Duijn, Esther, Kõrgvee, Lenne‐Triin, Maruszak, Wioleta, Grynkiewicz, Grzegorz, Garner, R. Colin, Knibbe, Catherijne A.J., Tibboel, Dick, de Wildt, Saskia N., Turner, Mark A.
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6783587/
https://ncbi.nlm.nih.gov/pubmed/31269280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.14047
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