The Oral Bioavailability and Metabolism of Midazolam in Stable Critically Ill Children: A Pharmacokinetic Microtracing Study

Midazolam is metabolized by the developmentally regulated intestinal and hepatic drug‐metabolizing enzyme cytochrome P450 (CYP) 3A4/5. It is frequently administered orally to children, yet knowledge is lacking on the oral bioavailability in term neonates up until 1 year of age. Furthermore, the disp...

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Publicado en:Clin Pharmacol Ther
Autores principales: van Groen, Bianca D., Krekels, Elke H. J., Mooij, Miriam G., van Duijn, Esther, Vaes, Wouter H. J., Windhorst, Albert D., van Rosmalen, Joost, Hartman, Stan J. F., Hendrikse, N. Harry, Koch, Birgit C. P., Allegaert, Karel, Tibboel, Dick, Knibbe, Catherijne A. J., de Wildt, Saskia N.
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7818442/
https://ncbi.nlm.nih.gov/pubmed/32403162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1890
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