The Oral Bioavailability and Metabolism of Midazolam in Stable Critically Ill Children: A Pharmacokinetic Microtracing Study

Midazolam is metabolized by the developmentally regulated intestinal and hepatic drug‐metabolizing enzyme cytochrome P450 (CYP) 3A4/5. It is frequently administered orally to children, yet knowledge is lacking on the oral bioavailability in term neonates up until 1 year of age. Furthermore, the disp...

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Vydáno v:Clin Pharmacol Ther
Hlavní autoři: van Groen, Bianca D., Krekels, Elke H. J., Mooij, Miriam G., van Duijn, Esther, Vaes, Wouter H. J., Windhorst, Albert D., van Rosmalen, Joost, Hartman, Stan J. F., Hendrikse, N. Harry, Koch, Birgit C. P., Allegaert, Karel, Tibboel, Dick, Knibbe, Catherijne A. J., de Wildt, Saskia N.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2020
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7818442/
https://ncbi.nlm.nih.gov/pubmed/32403162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1890
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