Successful Use of [(14)C]Paracetamol Microdosing to Elucidate Developmental Changes in Drug Metabolism

BACKGROUND: We previously showed the practical and ethical feasibility of using [(14)C]-microdosing for pharmacokinetic studies in children. We now aimed to show that this approach can be used to elucidate developmental changes in drug metabolism, more specifically, glucuronidation and sulfation, us...

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Bibliografische gegevens
Gepubliceerd in:Clin Pharmacokinet
Hoofdauteurs: Mooij, Miriam G., van Duijn, Esther, Knibbe, Catherijne A. J., Allegaert, Karel, Windhorst, Albert D., van Rosmalen, Joost, Hendrikse, N. Harry, Tibboel, Dick, Vaes, Wouter H. J., de Wildt, Saskia N.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Springer International Publishing 2017
Onderwerpen:
Original Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5591809/
https://ncbi.nlm.nih.gov/pubmed/28155137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-017-0508-6
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