Successful Use of [(14)C]Paracetamol Microdosing to Elucidate Developmental Changes in Drug Metabolism

BACKGROUND: We previously showed the practical and ethical feasibility of using [(14)C]-microdosing for pharmacokinetic studies in children. We now aimed to show that this approach can be used to elucidate developmental changes in drug metabolism, more specifically, glucuronidation and sulfation, us...

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Detalhes bibliográficos
Publicado no:Clin Pharmacokinet
Main Authors: Mooij, Miriam G., van Duijn, Esther, Knibbe, Catherijne A. J., Allegaert, Karel, Windhorst, Albert D., van Rosmalen, Joost, Hendrikse, N. Harry, Tibboel, Dick, Vaes, Wouter H. J., de Wildt, Saskia N.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2017
Assuntos:
Original Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5591809/
https://ncbi.nlm.nih.gov/pubmed/28155137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-017-0508-6
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