Pediatric Microdose Study of [(14)C]Paracetamol to Study Drug Metabolism Using Accelerated Mass Spectrometry: Proof of Concept

BACKGROUND: Pediatric drug development is hampered by practical, ethical, and scientific challenges. Microdosing is a promising new method to obtain pharmacokinetic data in children with minimal burden and minimal risk. The use of a labeled oral microdose offers the added benefit to study intestinal...

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Main Authors: Mooij, Miriam G., van Duijn, Esther, Knibbe, Catherijne A. J., Windhorst, Albert D., Hendrikse, N. Harry, Vaes, Wouter H. J., Spaans, Edwin, Fabriek, Babs O., Sandman, Hugo, Grossouw, Dimitri, Hanff, Lidwien M., Janssen, Paul J. J. M., Koch, Birgit C. P., Tibboel, Dick, de Wildt, Saskia N.
Format: Artigo
Jezik:Inglês
Izdano: Springer International Publishing 2014
Teme:
Short Communication
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4213380/
https://ncbi.nlm.nih.gov/pubmed/25227283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-014-0176-8
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