Proof of Concept: First Pediatric [(14)C]microtracer Study to Create Metabolite Profiles of Midazolam

Growth and development affect drug‐metabolizing enzyme activity thus could alter the metabolic profile of a drug. Traditional studies to create metabolite profiles and study the routes of excretion are unethical in children due to the high radioactive burden. To overcome this challenge, we aimed to...

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Detalhes bibliográficos
Publicado no:Clin Pharmacol Ther
Main Authors: van Groen, Bianca D., van Duijn, Esther, de Vries, Arjan, Mooij, Miriam G., Tibboel, Dick, Vaes, Wouter H. J., de Wildt, Saskia N.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7689753/
https://ncbi.nlm.nih.gov/pubmed/32386327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1884
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