Proof of Concept: First Pediatric [(14)C]microtracer Study to Create Metabolite Profiles of Midazolam

Growth and development affect drug‐metabolizing enzyme activity thus could alter the metabolic profile of a drug. Traditional studies to create metabolite profiles and study the routes of excretion are unethical in children due to the high radioactive burden. To overcome this challenge, we aimed to...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Clin Pharmacol Ther
Prif Awduron: van Groen, Bianca D., van Duijn, Esther, de Vries, Arjan, Mooij, Miriam G., Tibboel, Dick, Vaes, Wouter H. J., de Wildt, Saskia N.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2020
Pynciau:
Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7689753/
https://ncbi.nlm.nih.gov/pubmed/32386327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1884
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