Developmental changes rather than repeated administration drive paracetamol glucuronidation in neonates and infants

PURPOSE: Based on recovered metabolite ratios in urine, it has been concluded that paracetamol glucuronidation may be up-regulated upon multiple dosing. This study investigates paracetamol clearance in neonates and infants after single and multiple dosing using a population modelling approach. METHO...

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Bibliographic Details
Published in:Eur J Clin Pharmacol
Main Authors: Krekels, Elke H. J., van Ham, Saskia, Allegaert, Karel, de Hoon, Jan, Tibboel, Dick, Danhof, Meindert, Knibbe, Catherijne A. J.
Format: Artigo
Language:Inglês
Published: Springer Berlin Heidelberg 2015
Subjects:
Pharmacokinetics and Disposition
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4532713/
https://ncbi.nlm.nih.gov/pubmed/26139379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00228-015-1887-y
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