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Developmental changes rather than repeated administration drive paracetamol glucuronidation in neonates and infants
PURPOSE: Based on recovered metabolite ratios in urine, it has been concluded that paracetamol glucuronidation may be up-regulated upon multiple dosing. This study investigates paracetamol clearance in neonates and infants after single and multiple dosing using a population modelling approach. METHO...
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| 出版年: | Eur J Clin Pharmacol |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Springer Berlin Heidelberg
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4532713/ https://ncbi.nlm.nih.gov/pubmed/26139379 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00228-015-1887-y |
| タグ: |
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