A Bodyweight-Dependent Allometric Exponent for Scaling Clearance Across the Human Life-Span

PURPOSE: To explore different allometric equations for scaling clearance across the human life-span using propofol as a model drug. METHODS: Data from seven previously published propofol studies ((pre)term neonates, infants, toddlers, children, adolescents and adults) were analysed using NONMEM VI....

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Autori principali: Wang, Chenguang, Peeters, Mariska Y. M., Allegaert, Karel, Blussé van Oud-Alblas, Heleen J., Krekels, Elke H. J., Tibboel, Dick, Danhof, Meindert, Knibbe, Catherijne A. J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer US 2012
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3349030/
https://ncbi.nlm.nih.gov/pubmed/22287046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-012-0668-x
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