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A Bodyweight-Dependent Allometric Exponent for Scaling Clearance Across the Human Life-Span
PURPOSE: To explore different allometric equations for scaling clearance across the human life-span using propofol as a model drug. METHODS: Data from seven previously published propofol studies ((pre)term neonates, infants, toddlers, children, adolescents and adults) were analysed using NONMEM VI....
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Springer US
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3349030/ https://ncbi.nlm.nih.gov/pubmed/22287046 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-012-0668-x |
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