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The role of population PK–PD modelling in paediatric clinical research

Children differ from adults in their response to drugs. While this may be the result of changes in dose exposure (pharmacokinetics [PK]) and/or exposure response (pharmacodynamics [PD]) relationships, the magnitude of these changes may not be solely reflected by differences in body weight. As a cons...

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Hlavní autoři: De Cock, Roosmarijn F. W., Piana, Chiara, Krekels, Elke H. J., Danhof, Meindert, Allegaert, Karel, Knibbe, Catherijne A. J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer-Verlag 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3082690/
https://ncbi.nlm.nih.gov/pubmed/20340012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00228-009-0782-9
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