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The role of population PK–PD modelling in paediatric clinical research

Children differ from adults in their response to drugs. While this may be the result of changes in dose exposure (pharmacokinetics [PK]) and/or exposure response (pharmacodynamics [PD]) relationships, the magnitude of these changes may not be solely reflected by differences in body weight. As a cons...

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Bibliografische gegevens
Hoofdauteurs: De Cock, Roosmarijn F. W., Piana, Chiara, Krekels, Elke H. J., Danhof, Meindert, Allegaert, Karel, Knibbe, Catherijne A. J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Springer-Verlag 2010
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3082690/
https://ncbi.nlm.nih.gov/pubmed/20340012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00228-009-0782-9
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