Allometric Scaling of Clearance in Paediatric Patients: When Does the Magic of 0.75 Fade?

Allometric scaling on the basis of bodyweight raised to the power of 0.75 (AS0.75) is frequently used to scale size-related changes in plasma clearance (CL(p)) from adults to children. A systematic assessment of its applicability is undertaken for scenarios considering size-related changes with and...

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Опубликовано в: :Clin Pharmacokinet
Главные авторы: Calvier, Elisa A. M., Krekels, Elke H. J., Välitalo, Pyry A. J., Rostami-Hodjegan, Amin, Tibboel, Dick, Danhof, Meindert, Knibbe, Catherijne A. J.
Формат: Artigo
Язык:Inglês
Опубликовано: Springer International Publishing 2016
Предметы:
Original Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5315734/
https://ncbi.nlm.nih.gov/pubmed/27510367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-016-0436-x
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