Drugs Being Eliminated via the Same Pathway Will Not Always Require Similar Pediatric Dose Adjustments

For scaling drug plasma clearance (CLp) from adults to children, extrapolations of population pharmacokinetic (PopPK) covariate models between drugs sharing an elimination pathway have enabled accelerated development of pediatric models and dosing recommendations. This study aims at identifying cond...

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Publicat a:CPT Pharmacometrics Syst Pharmacol
Autors principals: Calvier, Elisa A. M., Krekels, Elke H. J., Yu, Huixin, Välitalo, Pyry A. J., Johnson, Trevor N., Rostami‐Hodjegan, Amin, Tibboel, Dick, van der Graaf, Piet H., Danhof, Meindert, Knibbe, Catherijne A. J.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5869561/
https://ncbi.nlm.nih.gov/pubmed/29399979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12273
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