Scaling Drug Clearance from Adults to the Young Children for Drugs Undergoing Hepatic Metabolism: A Simulation Study to Search for the Simplest Scaling Method

Previous research showed that scaling drug clearance from adults to children based on body weight alone is not accurate for all hepatically cleared drugs in very young children. This study systematically assesses the accuracy of scaling methods that, in addition to body weight, also take age-based v...

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Bibliografiska uppgifter
I publikationen:AAPS J
Huvudupphovsmän: Calvier, E. A. M., Krekels, E. H. J., Johnson, T. N., Rostami-Hodjegan, A., Tibboel, D., Knibbe, Catherijne A. J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Springer International Publishing 2019
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6505506/
https://ncbi.nlm.nih.gov/pubmed/30850923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-019-0295-0
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