Scaling Drug Clearance from Adults to the Young Children for Drugs Undergoing Hepatic Metabolism: A Simulation Study to Search for the Simplest Scaling Method

Previous research showed that scaling drug clearance from adults to children based on body weight alone is not accurate for all hepatically cleared drugs in very young children. This study systematically assesses the accuracy of scaling methods that, in addition to body weight, also take age-based v...

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Bibliographische Detailangaben
Veröffentlicht in:AAPS J
Hauptverfasser: Calvier, E. A. M., Krekels, E. H. J., Johnson, T. N., Rostami-Hodjegan, A., Tibboel, D., Knibbe, Catherijne A. J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer International Publishing 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6505506/
https://ncbi.nlm.nih.gov/pubmed/30850923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-019-0295-0
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