The Influence of Drug Properties and Ontogeny of Transporters on Pediatric Renal Clearance through Glomerular Filtration and Active Secretion: a Simulation-Based Study

Glomerular filtration (GF) and active tubular secretion (ATS) contribute to renal drug elimination, with the latter remaining understudied across the pediatric age range. Therefore, we systematically analyzed the influence of transporter ontogeny on the relative contribution of GF and ATS to renal c...

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Detalles Bibliográficos
Publicado en:AAPS J
Main Authors: Cristea, Sînziana, Krekels, Elke Henriëtte Josephina, Rostami-Hodjegan, Amin, Allegaert, Karel, Knibbe, Catherijne Annette Jantine
Formato: Artigo
Idioma:Inglês
Publicado: Springer International Publishing 2020
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7306484/
https://ncbi.nlm.nih.gov/pubmed/32566984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-020-00468-7
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