The Influence of Drug Properties and Ontogeny of Transporters on Pediatric Renal Clearance through Glomerular Filtration and Active Secretion: a Simulation-Based Study

Glomerular filtration (GF) and active tubular secretion (ATS) contribute to renal drug elimination, with the latter remaining understudied across the pediatric age range. Therefore, we systematically analyzed the influence of transporter ontogeny on the relative contribution of GF and ATS to renal c...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:AAPS J
Hoofdauteurs: Cristea, Sînziana, Krekels, Elke Henriëtte Josephina, Rostami-Hodjegan, Amin, Allegaert, Karel, Knibbe, Catherijne Annette Jantine
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Springer International Publishing 2020
Onderwerpen:
Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7306484/
https://ncbi.nlm.nih.gov/pubmed/32566984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-020-00468-7
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items