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Allometric Scaling of Clearance in Paediatric Patients: When Does the Magic of 0.75 Fade?
Allometric scaling on the basis of bodyweight raised to the power of 0.75 (AS0.75) is frequently used to scale size-related changes in plasma clearance (CL(p)) from adults to children. A systematic assessment of its applicability is undertaken for scenarios considering size-related changes with and...
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| Pubblicato in: | Clin Pharmacokinet |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Springer International Publishing
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5315734/ https://ncbi.nlm.nih.gov/pubmed/27510367 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-016-0436-x |
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