The Oral Bioavailability and Metabolism of Midazolam in Stable Critically Ill Children: A Pharmacokinetic Microtracing Study

Midazolam is metabolized by the developmentally regulated intestinal and hepatic drug‐metabolizing enzyme cytochrome P450 (CYP) 3A4/5. It is frequently administered orally to children, yet knowledge is lacking on the oral bioavailability in term neonates up until 1 year of age. Furthermore, the disp...

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發表在:Clin Pharmacol Ther
Main Authors: van Groen, Bianca D., Krekels, Elke H. J., Mooij, Miriam G., van Duijn, Esther, Vaes, Wouter H. J., Windhorst, Albert D., van Rosmalen, Joost, Hartman, Stan J. F., Hendrikse, N. Harry, Koch, Birgit C. P., Allegaert, Karel, Tibboel, Dick, Knibbe, Catherijne A. J., de Wildt, Saskia N.
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2020
主題:
Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7818442/
https://ncbi.nlm.nih.gov/pubmed/32403162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1890
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