Expression of Human Apolipoprotein E3 or E4 in the Brains ofApoe(−/−) Mice: Isoform-Specific Effects on Neurodegeneration

Apolipoprotein (apo) E isoforms are key determinants of susceptibility to Alzheimer’s disease. The apoE4 isoform is the major known genetic risk factor for this disease and is also associated with poor outcome after acute head trauma or stroke. To test the hypothesis that apoE3, but not apoE4, prote...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Buttini, Manuel, Orth, Matthias, Bellosta, Stefano, Akeefe, Hassibullah, Pitas, Robert E., Wyss-Coray, Tony, Mucke, Lennart, Mahley, Robert W.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 1999
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6782676/
https://ncbi.nlm.nih.gov/pubmed/10366621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.19-12-04867.1999
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