Cellular Source of Apolipoprotein E4 Determines Neuronal Susceptibility to Excitotoxic Injury in Transgenic Mice

The lipid transport protein apolipoprotein E (apoE) is abundantly expressed in the brain. Its main isoforms in humans are apoE2, apoE3, and apoE4. ApoE4 is the major known genetic risk factor for Alzheimer’s disease and also contributes to the pathogenesis of various other neurological conditions. I...

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Detalhes bibliográficos
Main Authors: Buttini, Manuel, Masliah, Eliezer, Yu, Gui-Qiu, Palop, Jorge J., Chang, Shengjun, Bernardo, Aubrey, Lin, Carol, Wyss-Coray, Tony, Huang, Yadong, Mucke, Lennart
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2010
Assuntos:
Short Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2913361/
https://ncbi.nlm.nih.gov/pubmed/20595630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090973
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