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Chronic Overproduction of Transforming Growth Factor-β1 by Astrocytes Promotes Alzheimer’s Disease-Like Microvascular Degeneration in Transgenic Mice

Cerebrovascular amyloid deposition and microvascular degeneration are frequently associated with Alzheimer’s disease (AD), but the etiology and pathogenetic role of these abnormalities are unknown. Recently, transforming growth factor-β1 (TGF-β1) was implicated in cerebrovascular amyloid formation i...

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Main Authors: Wyss-Coray, Tony, Lin, Carol, Sanan, David A., Mucke, Lennart, Masliah, Eliezer
Format: Artigo
Jezik:Inglês
Izdano: American Society for Investigative Pathology 2000
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Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868631/
https://ncbi.nlm.nih.gov/pubmed/10623661
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