Modulation of Alzheimer-Like Synaptic and Cholinergic Deficits in Transgenic Mice by Human Apolipoprotein E Depends on Isoform , Aging, and Overexpression of Amyloid β Peptides But Not on Plaque Formation

The most frequent human apolipoprotein (apo) E isoforms, E3 and E4, differentially affect Alzheimer's disease (AD) risk (E4 > E3) and age of onset (E4 < E3). Compared with apoE3, apoE4 promotes the cerebral deposition of amyloid β (Aβ) peptides, which are derived from the amyloid precurso...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Buttini, Manuel, Yu, Gui-Qiu, Shockley, Kristina, Huang, Yadong, Jones, Brian, Masliah, Eliezer, Mallory, Margaret, Yeo, Tracy, Longo, Frank M., Mucke, Lennart
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2002
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ARTICLE
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6758409/
https://ncbi.nlm.nih.gov/pubmed/12486146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.22-24-10539.2002
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