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Modulation of Alzheimer-Like Synaptic and Cholinergic Deficits in Transgenic Mice by Human Apolipoprotein E Depends on Isoform , Aging, and Overexpression of Amyloid β Peptides But Not on Plaque Formation
The most frequent human apolipoprotein (apo) E isoforms, E3 and E4, differentially affect Alzheimer's disease (AD) risk (E4 > E3) and age of onset (E4 < E3). Compared with apoE3, apoE4 promotes the cerebral deposition of amyloid β (Aβ) peptides, which are derived from the amyloid precurso...
Gorde:
| Argitaratua izan da: | J Neurosci |
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| Egile Nagusiak: | , , , , , , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Society for Neuroscience
2002
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6758409/ https://ncbi.nlm.nih.gov/pubmed/12486146 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.22-24-10539.2002 |
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