Neuron-Specific Apolipoprotein E4 Proteolysis Is Associated with Increased Tau Phosphorylation in Brains of Transgenic Mice

Apolipoprotein E (apoE) is found in amyloid plaques and neurofibrillary tangles (NFTs) in Alzheimer's disease (AD) brains, but its role in their pathogenesis is unclear. Previously, we found C-terminal-truncated fragments of apoE in AD brains and showed that such fragments can cause neurodegene...

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Detalles Bibliográficos
Publicado en:J Neurosci
Main Authors: Brecht, Walter J., Harris, Faith M., Chang, Shengjun, Tesseur, Ina, Yu, Gui-Qiu, Xu, Qin, Dee Fish, Jo, Wyss-Coray, Tony, Buttini, Manuel, Mucke, Lennart, Mahley, Robert W., Huang, Yadong
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2004
Assuntos:
Cellular/Molecular
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729489/
https://ncbi.nlm.nih.gov/pubmed/15014128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4315-03.2004
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