Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice

Apolipoprotein (apo) E4 increases the risk and accelerates the onset of Alzheimer's disease (AD). However, the underlying mechanisms remain to be determined. We previously found that apoE undergoes proteolytic cleavage in AD brains and in cultured neuronal cells, resulting in the accumulation o...

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Detalhes bibliográficos
Main Authors: Harris, Faith M., Brecht, Walter J., Xu, Qin, Tesseur, Ina, Kekonius, Lisa, Wyss-Coray, Tony, Fish, Jo Dee, Masliah, Eliezer, Hopkins, Paul C., Scearce-Levie, Kimberly, Weisgraber, Karl H., Mucke, Lennart, Mahley, Robert W., Huang, Yadong
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2003
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC196910/
https://ncbi.nlm.nih.gov/pubmed/12939405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1434398100
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