Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice

Apolipoprotein (apo) E4 increases the risk and accelerates the onset of Alzheimer's disease (AD). However, the underlying mechanisms remain to be determined. We previously found that apoE undergoes proteolytic cleavage in AD brains and in cultured neuronal cells, resulting in the accumulation o...

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Hlavní autoři: Harris, Faith M., Brecht, Walter J., Xu, Qin, Tesseur, Ina, Kekonius, Lisa, Wyss-Coray, Tony, Fish, Jo Dee, Masliah, Eliezer, Hopkins, Paul C., Scearce-Levie, Kimberly, Weisgraber, Karl H., Mucke, Lennart, Mahley, Robert W., Huang, Yadong
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2003
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC196910/
https://ncbi.nlm.nih.gov/pubmed/12939405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1434398100
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