Deficiency in neuronal TGF-β signaling promotes neurodegeneration and Alzheimer’s pathology

Alzheimer’s disease (AD) is characterized by progressive neurodegeneration and cerebral accumulation of the β-amyloid peptide (Aβ), but it is unknown what makes neurons susceptible to degeneration. We report that the TGF-β type II receptor (TβRII) is mainly expressed by neurons, and that TβRII level...

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Hauptverfasser: Tesseur, Ina, Zou, Kun, Esposito, Luke, Bard, Frederique, Berber, Elisabeth, Can, Judith Van, Lin, Amy H., Crews, Leslie, Tremblay, Patrick, Mathews, Paul, Mucke, Lennart, Masliah, Eliezer, Wyss-Coray, Tony
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2006
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1626127/
https://ncbi.nlm.nih.gov/pubmed/17080199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI27341
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