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Deficiency in neuronal TGF-β signaling promotes neurodegeneration and Alzheimer’s pathology
Alzheimer’s disease (AD) is characterized by progressive neurodegeneration and cerebral accumulation of the β-amyloid peptide (Aβ), but it is unknown what makes neurons susceptible to degeneration. We report that the TGF-β type II receptor (TβRII) is mainly expressed by neurons, and that TβRII level...
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| 主要な著者: | , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Clinical Investigation
2006
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1626127/ https://ncbi.nlm.nih.gov/pubmed/17080199 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI27341 |
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