Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice

Apolipoprotein (apo) E4 increases the risk and accelerates the onset of Alzheimer's disease (AD). However, the underlying mechanisms remain to be determined. We previously found that apoE undergoes proteolytic cleavage in AD brains and in cultured neuronal cells, resulting in the accumulation o...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Harris, Faith M., Brecht, Walter J., Xu, Qin, Tesseur, Ina, Kekonius, Lisa, Wyss-Coray, Tony, Fish, Jo Dee, Masliah, Eliezer, Hopkins, Paul C., Scearce-Levie, Kimberly, Weisgraber, Karl H., Mucke, Lennart, Mahley, Robert W., Huang, Yadong
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2003
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC196910/
https://ncbi.nlm.nih.gov/pubmed/12939405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1434398100
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