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Expression of Human Apolipoprotein E3 or E4 in the Brains ofApoe(−/−) Mice: Isoform-Specific Effects on Neurodegeneration

Apolipoprotein (apo) E isoforms are key determinants of susceptibility to Alzheimer’s disease. The apoE4 isoform is the major known genetic risk factor for this disease and is also associated with poor outcome after acute head trauma or stroke. To test the hypothesis that apoE3, but not apoE4, prote...

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Publicat a:J Neurosci
Autors principals: Buttini, Manuel, Orth, Matthias, Bellosta, Stefano, Akeefe, Hassibullah, Pitas, Robert E., Wyss-Coray, Tony, Mucke, Lennart, Mahley, Robert W.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 1999
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6782676/
https://ncbi.nlm.nih.gov/pubmed/10366621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.19-12-04867.1999
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