HIV Infected T Cells Can Proliferate in vivo Without Inducing Expression of the Integrated Provirus

BACKGROUND: HIV-1 proviruses can persist during ART in clonally-expanded populations of CD4+ T cells. To date, few examples of an expanded clones containing replication-competent proviruses exist, although it is suspected to be common. One such clone, denoted AMBI-1 (Maldarelli et al., 2014), was al...

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Vydáno v:Front Microbiol
Hlavní autoři: Musick, Andrew, Spindler, Jonathan, Boritz, Eli, Pérez, Liliana, Crespo-Vélez, Daniel, Patro, Sean C., Sobolewski, Michele D., Bale, Michael J., Reid, Carolyn, Keele, Brandon F., Capoferri, Adam, Shao, Wei, Wiegand, Ann, Simonetti, Francesco R., Mellors, John W., Hughes, Stephen H., Coffin, John M., Maldarelli, Frank, Kearney, Mary F.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Microbiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6781911/
https://ncbi.nlm.nih.gov/pubmed/31632364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2019.02204
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