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Early stage prion assembly involves two subpopulations with different quaternary structures and a secondary templating pathway

The dynamics of aggregation and structural diversification of misfolded, host-encoded proteins in neurodegenerative diseases are poorly understood. In many of these disorders, including Alzheimer’s, Parkinson’s and prion diseases, the misfolded proteins are self-organized into conformationally disti...

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Bibliografski detalji
Izdano u:Commun Biol
Glavni autori: Igel-Egalon, Angélique, Laferrière, Florent, Moudjou, Mohammed, Bohl, Jan, Mezache, Mathieu, Knäpple, Tina, Herzog, Laetitia, Reine, Fabienne, Jas-Duval, Christelle, Doumic, Marie, Rezaei, Human, Béringue, Vincent
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6778151/
https://ncbi.nlm.nih.gov/pubmed/31602412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0608-y
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